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We selected the 74 luxury monthly villas and homes worth renting in this location

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Home spotlights in Santo Spirito

Mars & Venus

Mars & Venus

  • 3 guests

  • 1 bedrooms

Santo Spirito, Florence

With views of the narrow Tuscan streets below, this sleek home’s interior is as pretty as the renaissance art the region is known for. Warm wood and shades of green sit in sharp contrast with the black of the kitchenette, and pop against the white that dominates most of the rest of the space.

The Palazzo Next Door

The Palazzo Next Door

  • 2 guests

  • 1 bedrooms

Santo Spirito, Florence

This charming apartment boasts a splendid location in Florence, overlooking the historic Palazzo Pitti and the Piazza Pitti. Windows in the bedroom look directly onto the iconic square – waking up here is a delight.

A Quiet Home

A Quiet Home

  • 2 guests

  • 1 bedrooms

Santo Spirito, Florence

Behind the grand stone walls of a 15th-century palace, this renaissance-painted apartment offers a beautiful base for discovering Florence. Found in the heart of the Oltrarno district – known for its local artisans and slower pace – it’s a peaceful retreat after a day exploring the city.

Frescoed Love

Frescoed Love

  • 6 guests

  • 2 bedrooms

San Giovanni, Florence

You’d be hard pressed to find a Florence apartment more central than this. All the sightseeing hotspots, including Ponte Vecchio, Piazza della Signoria, the Uffizi Gallery, and the Duomo, are within walking distance.


We selected the top 3% holiday homes in Santo Spirito Business Accommodation

Explore the 74 most perfect homes in our collection

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Most popular homes in Santo Spirito

The Heart of San Frediano

The Heart of San Frediano

  • 6 guests

  • 2 bedrooms

Santo Spirito, Florence

The Boboli Terrace

The Boboli Terrace

  • 4 guests

  • 2 bedrooms

Santo Spirito, Florence

Power of Presence

Power of Presence

  • 6 guests

  • 3 bedrooms

Santo Spirito, Florence

Grazie Mille

Grazie Mille

  • 6 guests

  • 3 bedrooms

Santo Spirito, Florence

Boboli Vista

Boboli Vista

  • 4 guests

  • 2 bedrooms

Santo Spirito, Florence

Terracotta & White Wood

Terracotta & White Wood

  • 6 guests

  • 3 bedrooms

Santo Spirito, Florence

Alberata Grande

Alberata Grande

  • 7 guests

  • 3 bedrooms

Santo Spirito, Florence

The Lights of Florence

The Lights of Florence

  • 5 guests

  • 3 bedrooms

San Giovanni, Florence

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Frequently asked questions

Searching for business accommodation in Santo Spirito, Florence, Tuscany, Italy? Plum Guide’s homes come fully furnished with the best-equipped kitchens, essential bathroom toiletries and all linen included. They have been tested and approved by our team of independent home critics, so you can rest assured that wifi speed or loud noises are not going to be a problem. Book today and enjoy a short or extended stay in the best business accommodation that Santo Spirito, Florence, Tuscany, Italy has to offer. Our friendly team of Plum Experts are on-hand 24/7 should you need anything.

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