San Diego Five Bedroom Homes

We selected the 408 homes worth renting in this location

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Home spotlights in San Diego

The Ocean Glimmer

The Ocean Glimmer

  • 10 guests

  • 5 bedrooms

Encinitas, San Diego County

With its views across Moonlight Beach, luxurious roof terrace and Scandinavian design, this is the kind of home that captivates you from the moment of arrival. And once inside, you might find it hard to leave.

Mountain Pose

Mountain Pose

  • 12 guests

  • 6 bedrooms

Yucca Valley, San Bernardino County

Set in acres and acres of untamed desert landscape, it doesn’t get much more serene than this palatial Joshua Tree villa. The surreal landscape of boulders and cacti is illuminated with custom lighting at night so you can admire it during a moonlight soak in the hot tub, or an evening dip in the sunken cowboy tub as the desert sky is speckled with stars.

Zenith Valley

Zenith Valley

  • 12 guests

  • 6 bedrooms

Yucca Valley, San Bernardino County

Visiting Joshua Tree is one thing, but seeing a big portion from the comfort of your bath is another. If the latter sounds like a bucket list goal, then Zenith Valley is for you.

Pacific Spirit

Pacific Spirit

  • 12 guests

  • 6 bedrooms

Lower Hermosa, San Diego

With direct access to Windansea Beach, this home makes the perfect setting for a laid-back coastal escape. You’ll be welcomed by beautiful views across La Jolla, a heated swimming pool and plenty of space to relax both inside and out.


We selected the top 3% holiday homes in San Diego Five Bedroom Homes

Explore the 408 most perfect homes in our collection

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Most popular homes in San Diego

Rock Bottom

Rock Bottom

  • 10 guests

  • 5 bedrooms

Mission Beach, San Diego

The Dawn Wall

The Dawn Wall

  • 10 guests

  • 5 bedrooms

San Clemente, Orange County

Rockin' in the Roundabout

Rockin' in the Roundabout

  • 10 guests

  • 5 bedrooms

Village of La Jolla, San Diego

April Showers

April Showers

  • 14 guests

  • 6 bedrooms

Indio, Riverside County

Straight From the Vine

Straight From the Vine

  • 18 guests

  • 8 bedrooms

Riverside County, California

Pearly Whites

Pearly Whites

  • 12 guests

  • 6 bedrooms

La Jolla Shores, San Diego

Hummingbird Dawn

Hummingbird Dawn

  • 8 guests

  • 5 bedrooms

Encinitas, San Diego County

Black Arrow

Black Arrow

  • 12 guests

  • 5 bedrooms

San Bernardino County, California

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Frequently asked questions

Spacious 5 bedroom homes in San Diego, San Diego County, California, United States. Plum Guide’s homes come fully furnished with the best-equipped kitchens, essential bathroom toiletries and all linen included. Book today and enjoy a short or extended stay in the best 5 bedroom homes that San Diego, San Diego County, California, United States has to offer. Our friendly team of Plum Experts are on-hand 24/7 should you need anything.

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