San Diego Five Bedroom Homes

We selected the 480 homes worth renting in this location

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Home spotlights in San Diego

The Ocean Glimmer

The Ocean Glimmer

  • 10 guests

  • 5 bedrooms

Encinitas, San Diego County

With its views across Moonlight Beach, luxurious roof terrace and Scandinavian design, this is the kind of home that captivates you from the moment of arrival. And once inside, you might find it hard to leave.

The Garden Cactus

The Garden Cactus

  • 12 guests

  • 5 bedrooms

La Quinta, Riverside County

This home, crowned by a backdrop of mountains, is ideal for group getaways to La Quinta. Surrounded by the Anza-Borrego Desert State Park, the famous Coachella Valley, and the iconic Joshua Tree, it's a gateway to hiking trails and golf courses.

Palm Springs Gem

Palm Springs Gem

  • 8 guests

  • 5 bedrooms

Historic Tennis Club, Palm Springs

Palm trees, cacti, and the San Jacinto Mountains as your backdrop – it doesn’t get more Palm Springs than this. Full of mid-century charm with all the modern comforts, it’s close to downtown but tucked away in a quiet spot.

Casa Molino

Casa Molino

  • 12 guests

  • 5 bedrooms

Rancho Santa Fe, San Diego County

Sophisticated, timeless and dazzling are just a few words to describe this stunning home in the Covenant in Rancho Santa Fe. Worthy of a magazine cover and set within an impressive two-acre estate, you're in for a memorable stay here.

We selected the top 3% holiday homes in San Diego Five Bedroom Homes

Explore the 480 most perfect homes in our collection

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Most popular homes in San Diego

Rock Bottom

Rock Bottom

  • 10 guests

  • 5 bedrooms

Mission Beach, San Diego

Black Arrow

Black Arrow

  • 12 guests

  • 5 bedrooms

Lake Arrowhead, San Bernardino County

Rockin' in the Roundabout

Rockin' in the Roundabout

  • 10 guests

  • 5 bedrooms

Village of La Jolla, San Diego

Golden State

Golden State

  • 8 guests

  • 5 bedrooms

Ventura, California

One Size Fits All

One Size Fits All

  • 32 guests

  • 16 bedrooms

Indian Wells, Riverside County

Looking Glass

Looking Glass

  • 10 guests

  • 5 bedrooms

Soledad South, San Diego

Blue Star

Blue Star

  • 8 guests

  • 5 bedrooms

Palacio Del Mar, San Diego

Cards on the Table

Cards on the Table

  • 14 guests

  • 6 bedrooms

Indio, Riverside County

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Frequently asked questions

Spacious 5 bedroom homes in San Diego, San Diego County, California, United States. Plum Guide’s homes come fully furnished with the best-equipped kitchens, essential bathroom toiletries and all linen included. Book today and enjoy a short or extended stay in the best 5 bedroom homes that San Diego, San Diego County, California, United States has to offer. Our friendly team of Plum Experts are on-hand 24/7 should you need anything.

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