Santa Maria Novella Five Bedroom Homes

We selected the 112 homes worth renting in this location

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Age 1 to 12

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Home spotlights in Santa Maria Novella

An Ode To Wine

An Ode To Wine

  • 14 guests

  • 5 bedrooms

Bagnolo-Cantagallo, Impruneta

Located on a hilltop in Florentine Chianti, this elegant, aristocratic home has glorious vistas over the surrounding hills, covered with vineyards and olive groves. It sits within a renowned wine estate producing excellent quality wines, which you can taste in the medieval cellar situated in the basement.

Tastes of Tuscany

Tastes of Tuscany

  • 17 guests

  • 7 bedrooms

Montelupo Fiorentino, Florence

With its hilltop setting in Tuscany, this home offers a picturesque escape. Olive trees and vineyards surround the home, composed of two villas restored to incorporate original features and charming decor.

Viti House

Viti House

  • 9 guests

  • 5 bedrooms

Scandicci, Florence

Cradled in the Tuscan Hills where Florence can be found only a short drive away, this beautiful home draws inspiration from the Renaissance the region is known for. Spot the influence in everything from the art to the carefully curated furniture as you wander the home looking for the perfect spot to read – we recommend the library or the drawing room where you’re mostly surrounded by floor-to-ceiling windows that let the light and sunshine in.

The Heart of Wonder

The Heart of Wonder

  • 10 guests

  • 5 bedrooms

San Giovanni, Florence

Located within a 16th-century Palazzo, this apartment offers a unique stay in the heart of Florence. From here, you can stroll to iconic sights like the Basilica of Santa Croce and Ponte Vecchio.


We selected the top 3% holiday homes in Santa Maria Novella Five Bedroom Homes

Explore the 112 most perfect homes in our collection

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Most popular homes in Santa Maria Novella

Top Lyric

Top Lyric

  • 10 guests

  • 5 bedrooms

San Lorenzo, Florence

Vines of Gold

Vines of Gold

  • 16 guests

  • 8 bedrooms

Bagno a Ripoli, Tuscany

Tuscan Glory

Tuscan Glory

  • 13 guests

  • 7 bedrooms

Bagno a Ripoli, Tuscany

Floral Dining

Floral Dining

  • 14 guests

  • 7 bedrooms

Rignano sull'Arno, Florence

La Dolce Spiaggia

La Dolce Spiaggia

  • 16 guests

  • 6 bedrooms

San Casciano in Val di Pesa, Florence

The Fountain of Wisdom

The Fountain of Wisdom

  • 9 guests

  • 5 bedrooms

San Giovanni, Florence

Eyes To The Sky

Eyes To The Sky

  • 12 guests

  • 5 bedrooms

San Marco, Florence

Villa Tosca

Villa Tosca

  • 16 guests

  • 8 bedrooms

La Chiocciola, Rignano sull'Arno

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Frequently asked questions

Spacious 5 bedroom homes in Santa Maria Novella. Plum Guide’s homes come fully furnished with the best-equipped kitchens, essential bathroom toiletries and all linen included. Book today and enjoy a short or extended stay in the best 5 bedroom homes that Santa Maria Novella has to offer. Our friendly team of Plum Experts are on-hand 24/7 should you need anything.

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