Book Luxury Airbnb Alternatives in Santo Spirito

We selected the 79 homes worth renting in this location

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Home spotlights in Santo Spirito

The Italian Way

The Italian Way

  • 12 guests

  • 4 bedrooms

Santo Spirito, Florence

Tradition and comfort go hand in hand in this Oltrarno apartment. Tucked within a Renaissance building, just moments from Ponte Vecchio, this is a great option for those seeking ease in a vibrant location.

The Basilica's Bell

The Basilica's Bell

  • 8 guests

  • 3 bedrooms

Santo Spirito, Florence

It feels like you can almost touch the Church of Santo Spirito from the windows of this apartment – we love the vistas here. You also get glimpses of the cathedral from the living room (which also sleeps guests seven and eight on a sofa bed).

Flower of Florence

Flower of Florence

  • 5 guests

  • 2 bedrooms

San Frediano, Florence

Found in the breathtaking city of Florence, this home also captures beauty in an understated way. With exposed beams, a neutral colour palette that works perfectly alongside the gold elements, and a touch of rustic, this home feels welcoming and cosy.

The Heart of San Frediano

The Heart of San Frediano

  • 6 guests

  • 2 bedrooms

Santo Spirito, Florence

Minutes south of the River Arno, this functional Florentine apartment is a solid option for families looking to explore the storied city. While it lacks a traditional living area – the sofa bed is found in an alcove beside the bathroom – there's still plenty of space to get settled, including a dining area for socialising and a good size master bedroom.


We selected the top 3% holiday homes in Santo Spirito Airbnb Alternatives

Explore the 79 most perfect homes in our collection

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Most popular homes in Santo Spirito

Astronomical Observatory View

Astronomical Observatory View

  • 6 guests

  • 2 bedrooms

San Frediano, Florence

Focal Length

Focal Length

  • 6 guests

  • 3 bedrooms

Santo Spirito, Florence

Aria to a Bird

Aria to a Bird

  • 2 guests

  • 1 bedrooms

Santo Spirito, Florence

Studio Florentine

Studio Florentine

  • 3 guests

  • 1 bedrooms

San Frediano, Florence

Florence Jewel

Florence Jewel

  • 4 guests

  • 2 bedrooms

Santo Spirito, Florence

The Boboli Terrace

The Boboli Terrace

  • 4 guests

  • 2 bedrooms

Santo Spirito, Florence

Between the Bridges

Between the Bridges

  • 6 guests

  • 3 bedrooms

San Giovanni, Florence

Palace on the Piazza

Palace on the Piazza

  • 7 guests

  • 4 bedrooms

San Frediano, Florence

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Frequently asked questions

Airbnb is a shot in the dark. We meticulously vet all our homes in Santo Spirito to ensure you won’t waste your precious holiday. Every home you'll find on Plum Guide comes fully furnished with the best-equipped kitchens, essential bathroom toiletries and all linen included. Before being accepted into our collection, each home much pass a meticulous vetting process, culminating in a personal home visit from an independent Home Critic. Rent one of Plum Guide's luxury Santo Spirito Airbnb Alternatives, and enjoy a long or short stay to remember. Should you need any assistance with your booking, our friendly team of experts will be on hand to guide you through the process.

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