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We selected the 74 luxury monthly villas and homes worth renting in this location

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Home spotlights in Santo Spirito

The Basilica's Bell

The Basilica's Bell

  • 8 guests

  • 3 bedrooms

Santo Spirito, Florence

It feels like you can almost touch the Church of Santo Spirito from the windows of this apartment – we love the vistas here. You also get glimpses of the cathedral from the living room (which also sleeps guests seven and eight on a sofa bed).

The Lyre Goddess

The Lyre Goddess

  • 2 guests

  • 1 bedrooms

San Frediano, Florence

Gazing up at the hand-painted frescoed ceiling, it's no surprise that we fell in love with this suite-style studio apartment. Though it's pocket-sized, it certainly packs a punch – after all, not much beats waking up to the sight of a lyre-playing goddess in a palazzo with ties to the Medici family.

Slow River

Slow River

  • 12 guests

  • 4 bedrooms

San Giovanni, Florence

In the heart of Florence, this home gives you the chance to experience the magic of Italian living. Consisting of two independent apartments on the same floor, this is a great option for groups and families with plenty of space to stretch out and unwind.

Focal Length

Focal Length

  • 6 guests

  • 3 bedrooms

Santo Spirito, Florence

What an outstanding location this fabulous home has in Florence – it's less than a minute's stroll from the medieval splendour of Ponte Vecchio. The magnificent Palazzo Pitti, one of Florence's largest architectural monuments, is a five-minute stroll away – a good time to visit is at sunset when the façade turns a pink hue.


We selected the top 3% holiday homes in Santo Spirito Long Stay Rentals

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Most popular homes in Santo Spirito

What a Pitti

What a Pitti

  • 4 guests

  • 2 bedrooms

Santo Spirito, Florence

Botticellian Beams

Botticellian Beams

  • 5 guests

  • 2 bedrooms

San Frediano, Florence

Arno View

Arno View

  • 6 guests

  • 2 bedrooms

Santo Spirito, Florence

A View of Dreams

A View of Dreams

  • 2 guests

  • 1 bedrooms

Santo Spirito, Florence

Fabulous In Florence

Fabulous In Florence

  • 7 guests

  • 3 bedrooms

San Frediano, Florence

The Florentine Tower

The Florentine Tower

  • 6 guests

  • 2 bedrooms

San Giovanni, Florence

Astronomical Observatory View

Astronomical Observatory View

  • 6 guests

  • 2 bedrooms

San Frediano, Florence

The Raffaella Rose

The Raffaella Rose

  • 3 guests

  • 1 bedrooms

San Frediano, Florence

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Frequently asked questions

Explore our collection of luxury Extended Stay Rentals available for you to rent in Santo Spirito, Florence, Tuscany, Italy. Each and every home you'll find has been through a meticulous, multi-stage vetting process to ensure quality our guests can always count on. The Long Stay Rentals in our Santo Spirito, Florence, Tuscany, Italy collection come fully furnished with well-equipped kitchens, all linens, and essential bathroom toiletries included. And if you need any assistance, our friendly team of experts is always on hand to help plan your perfect stay.

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