Rent Luxury Self-Catering Apartments in Santo Spirito

We selected the 80 homes worth renting in this location

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Home spotlights in Santo Spirito

Palazzo in the City

Palazzo in the City

  • 10 guests

  • 5 bedrooms

Santo Spirito, Florence

This elegant Florence apartment sits in a 15th‑century palazzo that blends centuries-old charm with modern comfort. Set in the heart of the historic Oltrarno district, it’s just moments from the Palazzo Pitti, Ponte Vecchio, and Boboli Gardens.

A Charming Haven

A Charming Haven

  • 10 guests

  • 4 bedrooms

Santo Spirito, Florence

Oenophiles, rejoice, for this elegant apartment is well-stocked with bottles from the hosts' own vineyard. More of a mixologist?

Soft Sunrise

Soft Sunrise

  • 2 guests

  • 1 bedrooms

Santo Spirito, Florence

Tucked in a historic building in the heart of Florence, this apartment offers a refreshing city sanctuary. Set across two floors, the rooms are simple and traditional with space to relax, unwind or catch up on work.

The Boboli Terrace

The Boboli Terrace

  • 4 guests

  • 2 bedrooms

Santo Spirito, Florence

Only a handful of homes in Florence overlook the beautiful Boboli Gardens – and this is one of them. Climb the spiral staircase to discover your own private terrace with a view, the perfect place to unwind after a day spent sightseeing.

We selected the top 3% holiday homes in Santo Spirito Self-Catering Apartments

Explore the 80 most perfect homes in our collection

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Most popular homes in Santo Spirito

What a Pitti

What a Pitti

  • 4 guests

  • 2 bedrooms

Santo Spirito, Florence

Pitti Pad

Pitti Pad

  • 8 guests

  • 4 bedrooms

Santo Spirito, Florence

Florence Elegant Retreat

Florence Elegant Retreat

  • 2 guests

  • 1 bedrooms

Santo Spirito, Florence

Brick & Arch

Brick & Arch

  • 4 guests

  • 1 bedrooms

Santo Spirito, Florence

Aria to a Bird

Aria to a Bird

  • 2 guests

  • 1 bedrooms

Santo Spirito, Florence

The Italian Way

The Italian Way

  • 12 guests

  • 4 bedrooms

Santo Spirito, Florence

Sunlight Spirit

Sunlight Spirit

  • 6 guests

  • 3 bedrooms

Santo Spirito, Florence

A Touch of Grace

A Touch of Grace

  • 5 guests

  • 2 bedrooms

Santo Spirito, Florence

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Frequently asked questions

Book luxury Self-Catering Apartments in Santo Spirito, Florence, Tuscany, Italy, and enjoy a memorable stay for all the right reasons. We leave no stone unturned in our pursuit of the most remarkable homes, vetting everything from shower pressure to design aesthetic. Every home in our collection of luxury Santo Spirito Self-Catering Rentals comes fully furnished with a well-equipped kitchen, all linens, and essential bathroom toiletries included. And should you need any help in finding the perfect home, our friendly experts are always on hand to help.

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